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Drug design and development. A realistic appraisal Alfred Burger pp 1 - 4; DOI: 10.1021/jm00199a001 |
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Potential antitumor agents. 26. Anionic congeners of the 9-anilinoacridines William A. Denny, Graham J. Atwell, and Bruce F. Cain pp 5 - 10; DOI: 10.1021/jm00199a002 |
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Nitrogen analogs of 1,4-benzoquinones. Activities against the ascitic sarcoma 180 of mice Ernest M. Hodnett, Gopalakrishnan Prakash, and Jafargholi Amirmoazzami pp 11 - 16; DOI: 10.1021/jm00199a003 |
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Structure-activity relationships in antitumor aniline mustards Augustine Panthananickal, Corwin Hansch, A. Leo, and Frank R. Quinn pp 16 - 26; DOI: 10.1021/jm00199a004 |
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Structure and tumor-promoting activity of analogs of anthralin (1,8-dihydroxy-9-anthrone) B. L. Van Duuren, A. Segal, S. S. Tseng, G. M. Rusch, G. Loewengart, U. Mate, D. Roth, A. Smith, S. Melchionne, and I. Seidman pp 26 - 31; DOI: 10.1021/jm00199a005 |
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Tumor inhibitors. 124. Structural requirements for antileukemic activity among the naturally occurring and semisynthetic maytansinoids S. Morris Kupchan, Albert T. Sneden, Alan R. Branfman, Gary A. Howie, Lionel I. Rebhun, Wilson E. McIvor, Regina W. Wang, and Terry C. Schnaitman pp 31 - 37; DOI: 10.1021/jm00199a006 |
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Study of chemical carcinogenesis. 7. Synthesis and mutagenicity of modified chrysenes related to the carcinogen, 5-methylchrysene Stephen S. Hecht, Myrna Loy, Robert Mazzarese, and Dietrich Hoffmann pp 38 - 44; DOI: 10.1021/jm00199a007 |
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Potential inhibitors of L-asparagine biosynthesis. 4. Substituted sulfonamide and sulfonylhydrazide analogs of L-asparagine Steven Brynes, Gilbert J. Burckart, and Michael Mokotoff pp 45 - 49; DOI: 10.1021/jm00199a008 |
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Analogs of ornithine as inhibitors of ornithine decarboxylase. New deductions concerning the topography of the enzyme's active site P. Bey, C. Danzin, V. Van Dorsselaer, P. Mamont, M. Jung, and C. Tardif pp 50 - 55; DOI: 10.1021/jm00199a009 |
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Selective monoamine oxidase inhibitors. 1. Compounds related to 4-aminophenethylamine Lennart Florvall, Anna Lena Ask, Sven Ove Ogren, and Svante B. Ross pp 56 - 63; DOI: 10.1021/jm00199a010 |
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Conformational analysis of the molecule luteinizing hormone-releasing hormone. 3. Analog inhibitors and antagonists Frank A. Momany pp 63 - 68; DOI: 10.1021/jm00199a011 |
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Adrenoceptor blocking agents. 2. 2-(.alpha.-Hydroxyarylmethyl)-3,3-dimethylaziridines, a new class of selective .beta.2-adrenoceptor antagonists Padam C. Jain, Y. Khandelwal, and Onkar N. Tripathi pp 68 - 72; DOI: 10.1021/jm00199a012 |
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Synthesis and adrenergic activity of benzimidazole bioisosteres of norepinephrine and isoproterenol Carroll D. Arnett, Jeremy Wright, and Nicolas Zenker pp 72 - 78; DOI: 10.1021/jm00199a013 |
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Antidepressant agents. 9. 3,3-Diphenylcyclobutylamines, a new class of central stimulants B. Carnmalm, S. Ramsby, A. L. Renyi, S. B. Ross, S. O. Ogren, and Nils E. Stjernstrom pp 78 - 82; DOI: 10.1021/jm00199a014 |
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Thiazolinone analogs of indolmycin with antiviral and antibacterial activity Michael R. Harnden, Stuart Bailey, Malcolm R. Boyd, Denis R. Taylor, and Nicholas D. Wright pp 82 - 87; DOI: 10.1021/jm00199a015 |
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Structure-activity relationships of dimeric Catharanthus alkaloids. 1. Deacetyl vinblastine amide (vindesine) sulfate Charles J. Barnett, George J. Cullinan, Koert Gerzon, Richard C. Hoying, William E. Jones, William M. Newlon, Gerald A. Poore, Robert L. Robison, Martin J. Sweeney, and et al. pp 88 - 96; DOI: 10.1021/jm00199a016 |
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Nucleosides. 107. Synthesis of 5-(.beta.-D-arabinofuranosyl)isocytosine and related C-nucleosides C. K. Chu, U. Reichman, K. A. Watanabe, and J. J. Fox pp 96 - 100; DOI: 10.1021/jm00199a017 |
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Quantum chemical studies of N-substituent variation in the oxymorphone series of opiate narcotics Gilda H. Loew and Donald S. Berkowitz pp 101 - 106; DOI: 10.1021/jm00199a018 |
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A novel synthesis and biological activity of several 5-halo-5'-amino analogs of deoxyribopyrimidine nucleosides Tai-Shun Lin and William H. Prusoff pp 106 - 109; DOI: 10.1021/jm00199a019 |
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Synthesis and biological activity of several amino analogs of thymidine Tai-Shun Lin and William H. Prusoff pp 109 - 112; DOI: 10.1021/jm00199a020 |
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Synthesis of 1-deaza-6-thioguanosine and 1-deaza-6-(methylthio)guanosine Robert D. Elliott and John A. Montgomery pp 112 - 114; DOI: 10.1021/jm00199a021 |
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Synthesis and some pharmacological properties of [4-.beta.-(2-thienyl)-L-alanine]oxytocin Clark W. Smith, Gerald Skala, and Roderich Walter pp 115 - 117; DOI: 10.1021/jm00199a022 |
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Replacement of the disulfide bond in oxytocin by an amide group. Synthesis and some biological properties of [cyclo-(1-L-aspartic acid, 6-L-.alpha.,.beta.-diaminopropionic acid)]oxytocin Clark W. Smith, Roderich Walter, Stanley Moore, Raymond C. Makofske, and Johannes Meienhofer pp 117 - 120; DOI: 10.1021/jm00199a023 |
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Peptide hormones. 109. Inhibitory analogs of the luteinizing hormone-releasing hormone having D-aromatic residues in positions 2 and 6 and variation in position 3 John Humphries, Yieh-Ping Wan, Karl Folkers, and Cyril Y. Bowers pp 120 - 123; DOI: 10.1021/jm00199a024 |
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Synthesis of heteroaromatic potential .beta.-adrenergic antagonists by the glycidol route Yulia Antonio, Catalina Camargo, Edwige Galeazzi, Jose Iriarte, Margarita Guzman, Joseph M. Muchowski, Kathie Gerrity, Frances Liu, Lois M. Miller, and Arthur M. Strosberg pp 123 - 126; DOI: 10.1021/jm00199a025 |
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Synthesis and comparative skeletal muscle relaxant activity of some 2,4-imidazolidinediones and their corresponding 5-hydroxy-2,4-imidazolidinediones K. O. Ellis, R. L. White, T. J. Schwan, and F. L. Wessels pp 127 - 130; DOI: 10.1021/jm00199a026 |
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Antineoplastic agents. 1. Synthesis and antineoplastic activities of chloroethyl- and methylnitrosourea analogs of thymidine Tai-Shun Lin, Paul H. Fischer, George T. Shiau, and William H. Prusoff pp 130 - 133; DOI: 10.1021/jm00199a027 |
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Modifications of primaquine as antimalarials. 2. 5-Phenylthio and 5-anilino derivatives of primaquine Keiichi Tanabe, Eugene H. Chen, Basant L. Verma, Andrew J. Saggiomo, and Edward A. Nodiff pp 133 - 136; DOI: 10.1021/jm00199a028 |
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[1-[3-(Phenothiazin-10-yl)propyl]-4-piperidinyl]phenylmethanones, a novel class of long-acting neuroleptic agents Robert F. Boswell, William J. Welstead, Robert L. Duncan, David N. Johnson, and William H. Funderburk pp 136 - 139; DOI: 10.1021/jm00199a029 |
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3-Benzazocine amidinium nitronates. An unusual type of opiate antagonist Michael J. Strauss, Raymond R. Bard, and Donald S. Robinson pp 139 - 140; DOI: 10.1021/jm00199a030 |
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Anomalous chiroptical properties of warfarin and phenprocoumon Edward J. Valente and William F. Trager pp 141 - 143; DOI: 10.1021/jm00199a031 |
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Phosphorus-nitrogen compounds. 21. Murine oncolytic and antifertility effect of adamantylaziridine compounds Lindley A. Cates, Michael B. Cramer, and Louis Williams pp 143 - 146; DOI: 10.1021/jm00199a032 |
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Book Reviews pp 146 - 152; DOI: 10.1021/jm00199a600 |
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X-ray analytical reexamination of correlation of nitrogen lone-pair orientation with analgetic activity Shunsaku Shiotani, Tadashi Kometani, Yoichi Iitaka, and Akiko Itai pp 153 - 154; DOI: 10.1021/jm00200a001 |
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A potential anti-Parkinson drug, N-n-propyl-N-n-butyl-.beta.-(3,4-dihydroxyphenyl)ethylamine hydrochloride, and its effects in intact and nigra-lesioned rats James Z. Ginos and Frances C. Brown pp 155 - 160; DOI: 10.1021/jm00200a002 |
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New dopaminergic and potential anti-Parkinson compounds, N,N-disubstituted .beta.-(3,4-dihydroxyphenyl)ethylamines James Z. Ginos, George C. Cotzias, and David Doroski pp 160 - 165; DOI: 10.1021/jm00200a003 |
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Study of the structural requirements for Dopa potentiation and oxotremorine antagonism by L-prolyl-L-leucylglycinamide Rodney L. Johnson, Edward E. Smissman, and Nicholas P. Plotnikoff pp 165 - 169; DOI: 10.1021/jm00200a004 |
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Methotrexate analogs. 10. Direct coupling of methotrexate and diethyl L-glutamate in the presence of peptide bond-forming reagents Andre Rosowsky and Cheng-Sein Yu pp 170 - 175; DOI: 10.1021/jm00200a005 |
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Effect of sparsomycin analogs on the puromycin-peptidyl transferase reaction on ribosomes Chang Kiu Lee and Robert Vince pp 176 - 179; DOI: 10.1021/jm00200a006 |
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[1-Deaminopenicillamine,4-threonine]oxytocin, a potent inhibitor of oxytocin Maurice Manning, John Lowbridge, Janny Seto, Jaya Haldar, and Wilbur H. Sawyer pp 179 - 182; DOI: 10.1021/jm00200a007 |
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Linked aryl aryloxypropanolamines as a new class of lipid catabolic agents Michael T. Cox, Stuart E. Jaggers, and Geraint Jones pp 182 - 188; DOI: 10.1021/jm00200a008 |
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Semisynthetic aminoglycoside antibacterials. 6. Synthesis of sisomicin, antibiotic G-52, and novel 6'-substituted analogs of sisomicin from aminoglycoside 66-40C D. Huw Davies, Alan K. Mallams, Mae Counelis, David Loebenberg, Eugene L. Moss, and J. Allan Waitz pp 189 - 193; DOI: 10.1021/jm00200a009 |
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Studies on anticoccidial agents. 12. Synthesis and anticoccidial activity of methyl-2(6)-nitro- and -3(5)-nitropyridinecarboxamides Yasuhiro Morisawa, Mitsuru Kataoka, Toshiaki Sakamoto, Hitoshi Nagahori, Noritoshi Kitano, and Kenichi Kusano pp 194 - 199; DOI: 10.1021/jm00200a010 |
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Antileukemic activity of ungeremine and related compounds. Preparation of analogs of ungeremine by a practical photochemical reaction Robert K. Y. Zee-Cheng, Shou-Jen Yan, and C. C. Cheng pp 199 - 203; DOI: 10.1021/jm00200a011 |
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Isolation, characterization, and properties of a labile hydrolysis product of the antitumor nucleoside, 5-azacytidine John A. Beisler pp 204 - 208; DOI: 10.1021/jm00200a012 |
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Studies on cyclophosphamide metabolites and their related compounds. 8. Synthesis and antitumor activity of preactivated isophosphamide analogs bearing modified alkylating functionalities Akira Takamizawa, Saichi Matsumoto, Tsuyoshi Iwata, Itsuo Makino, Kenji Yamaguchi, Naomi Uchida, Hisashi Kasai, Osamu Shiratori, and Shiro Takase pp 208 - 214; DOI: 10.1021/jm00200a013 |
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Relationship of molecular structure to in vivo scintigraphic distribution of carbon-11-labeled compounds. 4. Carbon-11-labeled mandelonitriles, mandelic acids and their esters Meldrum B. Winstead, Dennis A. Dougherty, Tz-Hong Lin, Archie Khentigan, James F. Lamb, and H. Saul Winchell pp 215 - 217; DOI: 10.1021/jm00200a014 |
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Relationship between structure and antineoplastic activity of arylsulfonylhydrazones of 2-formylpyridine N-oxide Krishna C. Agrawal and Alan C. Sartorelli pp 218 - 221; DOI: 10.1021/jm00200a015 |
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Chemical modification of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-.alpha.-D-glucopyranosyl)-D-glucitol Mitree M. Ponpipom, Robert L. Bugianesi, and Tsung-Ying Shen pp 221 - 225; DOI: 10.1021/jm00200a016 |
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Dehydrative metabolites of 1-(3-chlorophenyl)-1-methyl-2-phenyl-2-(2-pyridine)ethanol as potential hypocholesteremic agents J. M. Kokosa, J. E. Sinsheimer, D. R. Wade, J. C. Drach, and J. H. Burckhalter pp 225 - 228; DOI: 10.1021/jm00200a017 |
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5-O-Alkylated derivatives of 5-hydroxy-2'-deoxyuridine as potential antiviral agents. Anti-herpes activity of 5-propynyloxy-2'-deoxyuridine Paul F. Torrence, John W. Spencer, Albert M. Bobst, Johan Descamps, and Erik De Clercq pp 228 - 231; DOI: 10.1021/jm00200a018 |
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Conformations of selected 3-substituted 4-hydroxycoumarins in solution by nuclear magnetic resonance. Warfarin and phenprocoumon E. J. Valente, W. R. Porter, and W. F. Trager pp 231 - 234; DOI: 10.1021/jm00200a019 |
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Methyl 6-(phenylsulfinyl)imidazo[1,2-a]pyridine-2-carbamate, a potent, new anthelmintic Richard J. Bochis, Richard A. Dybas, Philip Eskola, Peter Kulsa, Bruce O. Linn, Aino Lusi, Eric P. Meitzner, John Milkowski, Helmut Mrozik, and et al. pp 235 - 237; DOI: 10.1021/jm00200a020 |
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Synthesis and analgetic activity of 1,2,3,4,5,6-hexahydro-1,6-methano-3-benzazocines Paul H. Mazzocchi and Aline M. Harrison pp 238 - 240; DOI: 10.1021/jm00200a021 |
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Hetacillin (R)- and (S)-sulfoxides. Synthesis and structure-activity relationships W. J. Gottstein, C. U. Kim, K. M. Shih, and D. N. McGregor pp 240 - 242; DOI: 10.1021/jm00200a022 |
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Book Reviews pp 242 - 244; DOI: 10.1021/jm00200a600 |
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Hypotensive phospholipids. Some stable analogs of Darmstoff Alfred N. Milbert and Robert A. Wiley pp 245 - 248; DOI: 10.1021/jm00201a001 |
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Preparation and biological actions of some symmetrically N,N-disubstituted dopamines Joseph G. Cannon, Fu-Lian Hsu, John Paul Long, Jan R. Flynn, Brenda Costall, and Robert J. Naylor pp 248 - 253; DOI: 10.1021/jm00201a002 |
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Acetylenics. 2. Synthesis and pharmacology of certain N,N-dialkyl-3-phenylpropyn-2-amines and some analogs with tryptamine-like behavioral effects in mice Madan M. Kwatra, David Z. Simon, Romano L. Salvador, and Paul D. Cooper pp 253 - 257; DOI: 10.1021/jm00201a003 |
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Analgesic and tranquilizing activity of 5,8-disubstituted 2-aminomethyl-3,4-dihydronaphthalenes Willard M. Welch, J. J. Plattner, Wilford P. Stratten, and C. A. Harbert pp 257 - 263; DOI: 10.1021/jm00201a004 |
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Diazepines. 5. Synthesis and biological action of 6-phenyl-4H-pyrrolo[1,2-a][1,4]benzodiazepines Takeshi Hara, Yasutaka Kayama, Toshiro Mori, Kazuhiko Itoh, Hitoshi Fujimori, Tamiko Sunami, Yoshinobu Hashimoto, and Sachio Ishimoto pp 263 - 268; DOI: 10.1021/jm00201a005 |
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Synthesis and antitumor activity of halogen-substituted 4-(3,3-dimethyl-1-triazeno)quinolines Ai Jeng Lin and Ti Li Loo pp 268 - 272; DOI: 10.1021/jm00201a006 |
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Bisamidines of 2,6-diaminoanthraquinone as antiamebic agents P. F. Fabio, T. L. Fields, Yang-I Lin, E. J. Burden, S. Carvajal, K. C. Murdock, and S. A. Lang pp 273 - 276; DOI: 10.1021/jm00201a007 |
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Branched-chain analogs of luteinizing hormone-releasing hormone Janos Seprodi, David H. Coy, Jesus A. Vilchez-Martinez, Escipion Pedroza, and Andrew V. Schally pp 276 - 280; DOI: 10.1021/jm00201a008 |
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Adriamycin analogs. 2. Synthesis of 13-deoxyanthracyclines Thomas H. Smith, Allan N. Fujiwara, and David W. Henry pp 280 - 283; DOI: 10.1021/jm00201a009 |
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Cardenolide analogs. 7. Synthesis and biological activity of some new steroidal guanylhydrazones Alex Gelbart and Richard Thomas pp 284 - 288; DOI: 10.1021/jm00201a010 |
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Metabolism of cis-.DELTA.4-15(S)-15-methylprostaglandin F1.alpha. methyl ester in the rat W. Gary Tarpley and Frank F. Sun pp 288 - 291; DOI: 10.1021/jm00201a011 |
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Antineoplastic agents. Structure-activity relationship study of bis(substituted aminoalkylamino)anthraquinones Robert K. Y. Zee-Cheng and C. C. Cheng pp 291 - 294; DOI: 10.1021/jm00201a012 |
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Synthesis of pyrimido[5,4-c]quinolines and related quinolines as potential antimalarials M. Nasr, I. Nabih, and J. H. Burckhalter pp 295 - 298; DOI: 10.1021/jm00201a013 |
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Imidazo[4,5-f]quinolines. 4. Synthesis and anthelmintic activity of a series of imidazo[4,5-f]quinolin-9-ols Robert J. Alaimo, Claude F. Spencer, James B. Sheffer, Ronald J. Storrin, Christopher J. Hatton, and Robert E. Kohls pp 298 - 300; DOI: 10.1021/jm00201a014 |
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Syntheses and biological activities of basically substituted isoalloxazines John P. Lambooy pp 301 - 303; DOI: 10.1021/jm00201a015 |
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Synthesis and antitumor properties of some isoindolylalkylphosphonium salts Ronald J. Dubois, Chie-Chang Lin, and John A. Beisler pp 303 - 306; DOI: 10.1021/jm00201a016 |
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A ureido group containing analog of oxytocin comprising eight amino acid residues Miklos Bodanszky, Daniel T. Fagan, Roderich Walter, and Clark W. Smith pp 306 - 308; DOI: 10.1021/jm00201a017 |
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Piperidylalkylindoles. 1. Hypotensive activity of 3-[2-(phenoxypiperidyl)ethyl]indoles Grover C. Helsley, Joseph Strupczewski, and David L. Woodward pp 309 - 312; DOI: 10.1021/jm00201a018 |
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[1-(.beta.-Mercapto-.beta.,.beta.-cyclopentamethylenepropionic acid),4-valine, 8-D-arginine]vasopressin, a potent and selective inhibitor of the vasopressor response to arginine-vasopressin John Lowbridge, Maurice Manning, Jaya Haldar, and Wilbur H. Sawyer pp 313 - 315; DOI: 10.1021/jm00201a019 |
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Book Reviews pp 315 - 320; DOI: 10.1021/jm00201a600 |
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Synthesis and biological evaluation of 10-oxa-11-deoxyprostaglandin E1 and 10-nor-9,11-secoprostaglandin F1 and their derivatives F. Ivy Carroll, Frank M. Hauser, Ronald C. Huffman, and Michael C. Coleman pp 321 - 325; DOI: 10.1021/jm00202a001 |
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Resolution of antimalarial agents via complex formation with .alpha.-(2,4,5,7-tetranitro-9-fluorenylideneaminooxy)propionic acid F. Ivy Carroll, Bertold Berrang, and C. P. Linn pp 326 - 330; DOI: 10.1021/jm00202a002 |
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Antimalarial drugs. 38. Folate antagonists. 10. Synthesis and antimalarial effects of 6-[[(aryl and aralkyl)amino]methyl]-2,4-pteridinediamines and -pteridinediamine 8-oxides Donald F. Worth, Judith Johnson, Edward F. Elslager, and Leslie M. Werbel pp 331 - 337; DOI: 10.1021/jm00202a003 |
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Folate antagonists. 11. Synthesis and antimalarial effects of 6-[(aryloxy- and arylthio-)methyl]-2,4-pteridinediamines and -pteridinediamine 8-oxides Leslie M. Werbel, Judith Johnson, Edward F. Elslager, and Donald F. Worth pp 337 - 339; DOI: 10.1021/jm00202a004 |
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Synthesis and antiarrhythmic activity of 2-dialkylaminoalkyl-9-phenyl-1H-indeno[2,1-c]pyridine derivatives Charles R. Ellefson, Chi M. Woo, and John W. Cusic pp 340 - 343; DOI: 10.1021/jm00202a005 |
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Synthesis and screening of 8-(4'-thiazolyl)purines A. Giner-Sorolla, J. T. Segarra, and M. H. Brooks pp 344 - 348; DOI: 10.1021/jm00202a006 |
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5-Chloro-2-phenyl-1-benzo[b]thiophene-3-alkanamines, potential antipsychotic agents Michael J. Kukla, Chi M. Woo, Janet R. Kehr, and Arni Miller pp 348 - 352; DOI: 10.1021/jm00202a007 |
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Synthesis of O-alkylated lysine-vasopressin, inhibitors of the antidiuretic response to lysine-vasopressin Lars Eric Larsson, Gunnar Lindeberg, Per Melin, and Vladimir Pliska pp 352 - 356; DOI: 10.1021/jm00202a008 |
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Synthetic carboxyl-containing polyethers, analogs of natural antibiotics John O. Gardner and Colin C. Beard pp 357 - 361; DOI: 10.1021/jm00202a009 |
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Chemical and electrochemical oxidation of 7-hydroxychlorpromazine Marilyn Neptune and Richard L. McCreery pp 362 - 368; DOI: 10.1021/jm00202a010 |
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Discriminant analysis and structure-activity relationships. 1. Naphthoquinones Gopalakrishnan Prakash and Ernest M. Hodnett pp 369 - 374; DOI: 10.1021/jm00202a011 |
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Activity-electroreduction relationship of antimicrobial metronidazole analogs Yie W. Chien and Seth S. Mizuba pp 374 - 380; DOI: 10.1021/jm00202a012 |
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Methotrexate analogs. 11. Unambiguous chemical synthesis and in vitro biological evaluation of .alpha.- and .gamma.-monoesters as potential prodrugs Andre Rosowsky, G. Peter Beardsley, William D. Ensminger, Herbert Lazarus, and Cheng-Sein Yu pp 380 - 386; DOI: 10.1021/jm00202a013 |
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Effects of molecular modification on hypocholesteremic activity of 1,3-bis(substituted phenoxy)-2-propanones and related derivatives Steven D. Wyrick and C. Piantadosi pp 386 - 390; DOI: 10.1021/jm00202a014 |
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Potential organ or tumor-imaging agents. 16. Fluorinated androstanes and the prostate Andre Castonguay, Raymond E. Counsell, R. W. Scot Skinner, and Rodney V. Pozderac pp 391 - 393; DOI: 10.1021/jm00202a015 |
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Ferrocenyl polyamines as agents for the chemoimmunotherapy of cancer Victor J. Fiorina, Ronald J. Dubois, and Steven Brynes pp 393 - 395; DOI: 10.1021/jm00202a016 |
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2,3-Dihydroxy-9-amino-9,10-dihydrophenanthrene, a rigid congener of dopamine and isoapomorphine David E. Nichols, John E. Toth, Jai D. Kohli, and Connie K. Kotake pp 395 - 398; DOI: 10.1021/jm00202a017 |
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Studies in the (+)-morphinan series. 5. Synthesis and biological properties of (+)-naloxone Ikuo Iijima, Junichi Minamikawa, Arthur E. Jacobson, Arnold Brossi, Kenner C. Rice, and Werner A. Klee pp 398 - 400; DOI: 10.1021/jm00202a018 |
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Spiro[isobenzofuran-1(3H),4'-piperidines]. 3. Diuretic and antihypertensive properties of compounds containing a sulfur attached to nitrogen Solomon S. Klioze and William J. Novick pp 400 - 403; DOI: 10.1021/jm00202a019 |
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Antitubercular 2,8-bis(alkylaminomethyl)phenazines K. C. Murdock, Yang-I Lin, J. P. Thomas, and S. A. Lang pp 403 - 405; DOI: 10.1021/jm00202a020 |
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2-(Alkoxyaryl)-2-imidazoline monoamine oxidase inhibitors with antidepressant activity Morton Harfenist, Francis E. Soroko, and Gerald M. McKenzie pp 405 - 409; DOI: 10.1021/jm00202a021 |
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Book Reviews pp 409 - 412; DOI: 10.1021/jm00202a600 |
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Nuclear analogs of .beta.-lactam antibiotics. 4. Total synthesis of bisnorisopenicillins from antibacterially active monocyclic .beta.-lactam precursors William F. Huffman, Ralph F. Hall, Janet A. Grant, and Kenneth G. Holden pp 413 - 415; DOI: 10.1021/jm00203a001 |
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Analgesics. 1. Synthesis and analgesic properties of N-sec-alkyl and N-tert-alkylnormorphines J. I. DeGraw, J. A. Lawson, J. L. Crase, H. L. Johnson, M. Ellis, E. T. Uyeno, G. H. Loew, and D. S. Berkowitz pp 415 - 422; DOI: 10.1021/jm00203a002 |
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Analgesics and narcotic antagonists in the benzomorphan and 8-oxamorphinan series. 5 Yvon Lambert, Jean Paul Daris, Ivo Monkovic, and Anthony W. Pircio pp 423 - 427; DOI: 10.1021/jm00203a003 |
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Synthesis and antiinflammatory activity of 6-oxo-1-(.beta.-D-ribofuranosyl)nicotinic acid and related derivatives Kenji Miyai, Richard L. Tolman, Roland K. Robins, and C. C. Cheng pp 427 - 430; DOI: 10.1021/jm00203a004 |
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Potential antitumor agents. 27. Quantitative structure-antileukemic (L1210) activity relationships for the .omega.[4-(9-acridinylamino)phenyl]alkanoic acids William A. Denny and Bruce F. Cain pp 430 - 437; DOI: 10.1021/jm00203a005 |
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(Acylaryloxy)acetic acid diuretics. 2. (2-Alkyl-2-aryl-1-oxo-5-indanyloxy)acetic acids S. Jane DeSolms, Otto W. Woltersdorf, Edward J. Cragoe, L. Sherman Watson, and George M. Fanelli pp 437 - 443; DOI: 10.1021/jm00203a006 |
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Prostaglandin analogs. 2. 15,15-Ketals of natural prostaglandins and prostaglandin analogs. Synthesis and biological activities W. Skuballa, B. Raduechel, O. Loge, W. Elger, and H. Vorbrueggen pp 443 - 447; DOI: 10.1021/jm00203a007 |
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Inhibitors of neuronal monoamine uptake. 2. Selective inhibition of 5-hydroxytryptamine uptake by .alpha.-amino acid esters of phenethyl alcohols Ulf Henrik Lindberg, Seth Olof Thorberg, Stefan Bengtsson, Anna L. Renyi, Svante B. Ross, and Sven Ove Ogren pp 448 - 456; DOI: 10.1021/jm00203a008 |
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Inactivation of trypsin-like proteases by sulfonylation. Variation of positively charged group and inhibitor length Show-Chu Wong, George D. J. Green, and Elliott Shaw pp 456 - 459; DOI: 10.1021/jm00203a009 |
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3-Aryl- and 3-hydroxy-3-aryloctahydropyrido[2,1-c][1,4]oxazines. Synthesis, stereochemistry, and central nervous system pharmacological actions Gary O. Rankin, Thomas N. Riley, and James C. Murphy pp 460 - 464; DOI: 10.1021/jm00203a010 |
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A Fujita-Ban structure-activity analysis of 44 steroids J. B. Justice pp 465 - 468; DOI: 10.1021/jm00203a011 |
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Molecular structure of 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea H. Warren Smith, Arthur Camerman, and Norman Camerman pp 468 - 471; DOI: 10.1021/jm00203a012 |
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Benzomorphans. Structure of a position isomer N. F. Albertson, W. F. Michne, and B. F. Tullar pp 471 - 474; DOI: 10.1021/jm00203a013 |
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Synthesis and analgesic activity of some long-acting piperidinospiro derivatives of methadone James M. Frincke, Gary L. Henderson, Paul A. J. Janssen, and Cyriel A. M. Van der Eycken pp 474 - 476; DOI: 10.1021/jm00203a014 |
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Synthesis and pharmacological activity of some derivatives of 1-phenyl-1,2,3,4-tetrahydro-5H-1,4-benzodiazepin-5-one C. Bagolini, P. De Witt, L. Pacifici, and M. T. Ramacci pp 476 - 480; DOI: 10.1021/jm00203a015 |
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Antiallergic 9-oxo-11-hydroxy-5H,9H-[2]benzopyrano[4,3-g][1]benzopyrans John P. Devlin, Armin Bauen, Genus J. Possanza, and P. Brian Stewart pp 480 - 483; DOI: 10.1021/jm00203a016 |
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Synthesis and antibacterial activity of isomeric 6- and 7-acetyl-3-methyl-2-quinoxalinecarboxamide 1,4-dioxides John P. Dirlam and Joseph E. Presslitz pp 483 - 485; DOI: 10.1021/jm00203a017 |
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Quinolone antimicrobial agents. 1. Versatile new synthesis of 1-alkyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids L. A. Mitscher, H. E. Gracey, G. W. Clark, and T. Suzuki pp 485 - 489; DOI: 10.1021/jm00203a018 |
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Synthesis and hypoglycemic activity of some substituted 2-arylthiazolo[3.2-a]pyridinium salts Benjamin Blank, Nicholas W. DiTullio, Arnold J. Krog, and Harry J. Saunders pp 489 - 492; DOI: 10.1021/jm00203a019 |
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Mitomycin antibiotics. Synthesis of 7-methoxy-1-(N-pyrrolidino)mitosene and its methiodide James Mott and William A. Remers pp 493 - 495; DOI: 10.1021/jm00203a020 |
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Selenium-sulfur analogs. 1. Synthesis and biochemical evaluation of selenotetramisole Robert N. Hanson, Roger W. Giese, Michael A. Davis, and Sheila M. Costello pp 496 - 498; DOI: 10.1021/jm00203a021 |
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Book Reviews pp 499 - 504; DOI: 10.1021/jm00203a600 |
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New synthetic calcium selective ionophores. Design, synthesis, and transport properties Michael J. Umen and A. Scarpa pp 505 - 506; DOI: 10.1021/jm00204a001 |
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Guanylhydrazones with potential antileukemic activity. 2. Synthesis and structure-activity relationships of analogs of 4,4'-diacetyl-N,N'-diphenylurea bis(guanylhydrazone) W. Korytnyk, N. Angelino, C. Dave, and L. Caballes pp 507 - 513; DOI: 10.1021/jm00204a002 |
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Synthesis, metabolism, and antitumor activity of deuterated analogs of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea Peter B. Farmer, Allan B. Foster, Michael Jarman, Malcolm R. Oddy, and Donald J. Reed pp 514 - 520; DOI: 10.1021/jm00204a003 |
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New inhibitors of platelet aggregation. 5'-Phosphate, 5'-phosphorothioate, and 5'-O-sulfamoyl derivatives of 2-substituted adenosine analogs Geoffrey R. Gough, Denis M. Nobbs, John C. Middleton, Fylia Penglis-Caredes, and M. Helen Maguire pp 520 - 525; DOI: 10.1021/jm00204a004 |
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Studies on drug metabolism by use of isotopes. 23. Metabolic study of 1-butyryl-4-cinnamylpiperazine in the rat during development of tolerance by using two kinds of deuterium-labeled forms Shigeo Baba, Sumio Kato, Shinichi Morishita, and Hisao Sone pp 525 - 529; DOI: 10.1021/jm00204a005 |
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Tricyclic aryl-substituted anticoccidial azauracils Arthur F. Kluge, Joan M. Caroon, Stefan H. Unger, and John F. Ryley pp 529 - 536; DOI: 10.1021/jm00204a006 |
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Piperazinylpyrazines with central serotoninmimetic activity William C. Lumma, Richard D. Hartman, Walfred S. Saari, Edward L. Engelhardt, Ralph Hirschmann, Bradley V. Clineschmidt, Mary Lou Torchiana, and Clement A. Stone pp 536 - 542; DOI: 10.1021/jm00204a007 |
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Novel anxiolytic agents derived from .alpha.-amino-.alpha.-phenyl-o-tolyl-4H-triazoles and -imidazoles Martin Gall, R. A. Lahti, A. D. Rudzik, D. J. Duchamp, C. Chidester, and T. Scahill pp 542 - 548; DOI: 10.1021/jm00204a008 |
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Oxidative and cardiovascular studies on natural and synthetic catecholamines Charles G. Chavdarian, Daiji Karashima, Neal Castagnoli, and Harvey K. Hundley pp 548 - 554; DOI: 10.1021/jm00204a009 |
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Effects of deuteration of locomotor activity of amphetamine Salem E. Najjar, Martin I. Blake, Philippe A. Benoit, and Matthias C. Lu pp 555 - 558; DOI: 10.1021/jm00204a010 |
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.beta.-D-Arabinofuran[1',2':4,5]oxazolo-1,3,5-triazine-5-N-methyl-4,6-dione and analogs, unusually specific immunosuppressive agents W. Wierenga, B. E. Loughman, A. J. Gibbons, and H. E. Renis pp 558 - 562; DOI: 10.1021/jm00204a011 |
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Antitumor 1-(X-aryl)-3,3-dialkyltriazenes. 1. Quantitative structure-activity relationships vs L1210 leukemia in mice Gerard J. Hatheway, Corwin Hansch, Ki Hwan Kim, Stanley R. Milstein, Charles L. Schmidt, R. Nelson Smith, and Frank R. Quinn pp 563 - 574; DOI: 10.1021/jm00204a012 |
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Antitumor 1-(X-aryl)-3,3-dialkyltriazenes. 2. On the role of correlation analysis in decision making in drug modification. Toxicity quantitative structure-activity relationships of 1-(X-phenyl)-3,3-dialkyltriazenes in mice Corwin Hansch, Gerard J. Hatheway, Frank R. Quinn, and Nathaniel Greenberg pp 574 - 577; DOI: 10.1021/jm00204a013 |
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Cytostatic quinones. 3. Synthesis of benzotriazolequinones by a new oxidation with m-chloroperbenzoic acid. Biochemical studies G. Alonso, A. Contreras, M. Fuertes, J. M. Infante, F. G. De las Heras, and M. Stud pp 578 - 582; DOI: 10.1021/jm00204a014 |
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Aroyl- and arylisoquinolineacetic acids as antiinflammatory agents David A. Walsh, Lawrence F. Sancilio, and Donna L. Reese pp 582 - 585; DOI: 10.1021/jm00204a015 |
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Synthesis of spiro[tetralin-2,2'-pyrrolidine] and spiro[indan-2,2'-pyrrolidine] derivatives as potential analgesics Peter A. Crooks and Howard E. Rosenberg pp 585 - 587; DOI: 10.1021/jm00204a016 |
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Antibacterial activity of N-(.beta.-styryl)formamides related to tuberin Ian T. Harrison, Walter Kurz, Ian J. Massey, and Stefan H. Unger pp 588 - 591; DOI: 10.1021/jm00204a017 |
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Syntheses and uncoupling activities of alkyl dithiocarbazates and alkyl pyridinecarbonyldithiocarbazates Seiju Kubota, Masayuki Uda, Yasuyuki Mori, Fujio Kametani, and Hiroshi Terada pp 591 - 594; DOI: 10.1021/jm00204a018 |
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Book Reviews pp 594 - 596; DOI: 10.1021/jm00204a600 |
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Novel arabinofuranosyl derivatives of cytosine resistant to enzymic deamination and possessing potent antitumor activity M. Bobek, Y. C. Cheng, and A. Bloch pp 597 - 598; DOI: 10.1021/jm00205a001 |
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6.beta.-[N,N-Bis(2-chloroethyl)amino]-17-(cyclopropylmethyl)-4,5.alpha.-epoxy-3,14-dihydroxymorphinan (chloranaltrexamine), a potent opioid receptor alkylating agent with ultralong narcotic antagonist activity P. S. Portoghese, D. L. Larson, J. B. Jiang, A. E. Takemori, and T. P. Caruso pp 598 - 599; DOI: 10.1021/jm00205a002 |
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Conformation of 2,9-dimethyl-3'-hydroxy-5-phenyl-6,7-benzomorphan and its relation to other analgetics and enkephalin Frank H. Clarke, Hermann Jaggi, and Richard A. Lovell pp 600 - 606; DOI: 10.1021/jm00205a003 |
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Synthesis and evaluation of bis-dipeptide and bis-tripeptide analogs of actinomycin D A. K. Azad Chowdhury, Jeffrey R. Brown, and Robert B. Longmore pp 607 - 612; DOI: 10.1021/jm00205a004 |
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Diarylamidine derivatives with one or both of the aryl moieties consisting of an indole or indole-like ring. Inhibitors of arginine-specific esteroproteases R. R. Tidwell, J. D. Geratz, O. Dann, G. Volz, D. Zeh, and H. Loewe pp 613 - 623; DOI: 10.1021/jm00205a005 |
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Synthesis and antiinflammatory activity of trisubstituted pyrimidines and triazines Gregory B. Bennett, Robert B. Mason, Lee J. Alden, and James B. Roach pp 623 - 628; DOI: 10.1021/jm00205a006 |
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Aromatic esters of nonquaternary carbon-4 piperidinols as analgesics James A. Waters pp 628 - 633; DOI: 10.1021/jm00205a007 |
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Nonsteroidal antiinflammatory agents. 2. Derivatives/analogs of dibenz[b,e]oxepin-3-acetic acid Toshiyuki Yoshioka, Masayuki Kitagawa, Masaharu Oki, Shiro Kubo, Hiroaki Tagawa, Katsujiro Ueno, Wataru Tsukada, Masao Tsubokawa, and Akira Kasahara pp 633 - 639; DOI: 10.1021/jm00205a008 |
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Antimalarial drugs. 40. Folate antagonists. 12. Antimalarial and antibacterial effects of 2,4-diamino-6-[(aralkyl and alicyclic)thio-, sulfinyl-, and sulfonyl]quinazolines Edward F. Elslager, John Davoll, Patricia Jacob, A. M. Johnson, Judith Johnson, and Leslie M. Werbel pp 639 - 643; DOI: 10.1021/jm00205a009 |
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A new class of antimalarial drugs: derivatives of benzothiopyrans Raj K. Razdan, Robert J. Bruni, Avinash C. Mehta, Klaus K. Weinhardt, and Zinon B. Papanastassiou pp 643 - 649; DOI: 10.1021/jm00205a010 |
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Synthesis of N-hydroxyacetaminophen, a postulated toxic metabolite of acetaminophen, and its phenolic sulfate conjugate Mark W. Gemborys, Gordon W. Gribble, and Gilbert H. Mudge pp 649 - 652; DOI: 10.1021/jm00205a011 |
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Anionic polymers and biological activities. Effects of some new polycarboxylic acids on the ascitic sarcoma 180 of mice Ernest M. Hodnett, J. Amirmoazzami, and Joseph Tien Hai Tai pp 652 - 657; DOI: 10.1021/jm00205a012 |
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Potential antitumor agents. 28. Deoxyribonucleic acid polyintercalating agents Bruce F. Cain, Bruce C. Baguley, and William A. Denny pp 658 - 668; DOI: 10.1021/jm00205a013 |
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Synthesis and antiallergic activity of some mono- and disubstituted xanthone-2-carboxylic acids Juerg R. Pfister, Rodolfo W. Ferraresi, Ian T. Harrison, Wendell H. Rooks, and John H. Fried pp 669 - 672; DOI: 10.1021/jm00205a014 |
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Folate analogs altered in the C9-N10 bridge region: N10-tosylisohomofolic acid and N10-tosylisohomoaminopterin M. G. Nair, P. Colleen O'Neal, C. M. Baugh, Roy L. Kisliuk, Y. Gaumont, and Michael Rodman pp 673 - 677; DOI: 10.1021/jm00205a015 |
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Alteration of relative affinities toward myocardial and vascular .beta. adrenoceptors induced by side-chain substitution of aryloxypropanolamines Gad Shtacher, Rachel Rubinstein, and Pitambar Somani pp 678 - 683; DOI: 10.1021/jm00205a016 |
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An ab initio study of electronic factors in metabolic hydroxylation of aliphatic carbon atoms Bernard Testa and Dia Mihailova pp 683 - 686; DOI: 10.1021/jm00205a017 |
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Electronic structures of some antimicrobial N-chloramines. Possible existence of intramolecular hydrogen bonding and its effect on germicidal efficiency Steven H. Gerson, S. D. Worley, N. Bodor, and J. J. Kaminski pp 686 - 688; DOI: 10.1021/jm00205a018 |
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Antiviral activity of some .beta.-diketones. 3. Aryl bis(.beta.-diketones). Antiherpetic activity Guy D. Diana, Philip M. Carabateas, U. Joseph Salvador, Gordon L. Williams, Ethel S. Zalay, Francis Pancic, B. A. Steinberg, and Joseph C. Collins pp 689 - 692; DOI: 10.1021/jm00205a019 |
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trans-2,3b,4,5,7,8b,9,10-Octahydronaphtho[1,2-c:5,6-c']dipyrazole, a new orally active antiallergic compound Maria J. Vitolo, Victor E. Marquez, and Ines Hurtado pp 692 - 694; DOI: 10.1021/jm00205a020 |
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Neuroleptics related to butaclamol. Synthesis and some psychopharmacological effects of a series of 3-aryl analogues Katherine Voith, Francois T. Bruderlein, and Leslie G. Humber pp 694 - 698; DOI: 10.1021/jm00205a021 |
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Antitumor agents. 31. Helenalin sym-dimethylethylenediamine reaction products and related derivatives Kuo-Hsiung Lee, Toshiro Ibuka, Eng-Chun Mar, and Iris H. Hall pp 698 - 701; DOI: 10.1021/jm00205a022 |
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Mercaptoimidazolylpropionic acid hydrobromide. Inhibition of tadpole collagenase and related properties John A. Yankeelov, Harlie A. Parish, and Arno F. Spatola pp 701 - 704; DOI: 10.1021/jm00205a023 |
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Nucleoside 5'-monophosphate analogues. Synthesis of 5'-sulfamino-5'-deoxynucleosides William S. Mungall, L. James Lemmen, Kathleen L. Lemmen, Judy Kaiser Dethmers, and Laura L. Norling pp 704 - 706; DOI: 10.1021/jm00205a024 |
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Synthesis of branched-chain apiosylpyrimidines and their inhibition of lymphocyte proliferation Dilipkumar K. Parikh and Ronald R. Watson pp 706 - 709; DOI: 10.1021/jm00205a025 |
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5-Carboxamido-4-amino-3-isoxazolidone, an asparagine analog Charles H. Stammer and Masayuki Sato pp 709 - 712; DOI: 10.1021/jm00205a026 |
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Steroid antifertility agents. Ionic complexes of basic derivatives for prolonged action Allan P. Gray and Terry N. Yamauchi pp 712 - 715; DOI: 10.1021/jm00205a027 |
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Solution conformations of muscarine and some analogs Dusk L. De Fontaine, Bela Ternai, J. A. Zupan, R. S. Givens, and R. A. Wiley pp 715 - 717; DOI: 10.1021/jm00205a028 |
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Book Reviews pp 717 - 720; DOI: 10.1021/jm00205a600 |
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N-hydroxyamide metabolites of lidocaine. Synthesis, characterization, quantitation, and mutagenic potential Sidney D. Nelson, Wendel L. Nelson, and William F. Trager pp 721 - 725; DOI: 10.1021/jm00206a001 |
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Metabolic fate of tolazamide in man and in the rat Richard C. Thomas, David J. Duchamp, Ray W. Judy, and George J. Ikeda pp 725 - 732; DOI: 10.1021/jm00206a002 |
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Antitumor anthracycline antibiotics. Structure-activity and structure-cardiotoxicity relationships of rubidazone analogs George L. Tong, Michael Cory, William W. Lee, David W. Henry, and Gerhardt Zbinden pp 732 - 737; DOI: 10.1021/jm00206a003 |
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Studies on antitumor agents. 2. Syntheses and antitumor activities of 1-(tetrahydro-2-furanyl)-5-fluorouracil and 1,3-bis(tetrahydro-2-furanyl)-5-fluorouracil Mitsugi Yasumoto, Ichiro Yamawaki, Teruyoshi Marunaka, and Sadao Hashimoto pp 738 - 741; DOI: 10.1021/jm00206a004 |
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Synthesis and antiviral activity of some phosphates of the broad-spectrum antiviral nucleoside, 1-.beta.-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (ribavirin) Lois B. Allen, K. H. Boswell, Tasneem A. Khwaja, Rich B. Meyer, Robert W. Sidwell, J. T. Witkowski, Leon F. Christensen, and Roland K. Robins pp 742 - 746; DOI: 10.1021/jm00206a005 |
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Synthesis and antihypertensive activity of some ester progenitors of methyldopa Walfred S. Saari, Mark B. Freedman, Richard D. Hartman, Stella W. King, Andrew W. Raab, William C. Randall, Edward L. Engelhardt, Ralph Hirschmann, Avery Rosegay, and et al. pp 746 - 753; DOI: 10.1021/jm00206a006 |
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Ergot alkaloids. 87. New ergolines as selective dopaminergic stimulants Peter L. Stuetz, Paul A. Stadler, Jean M. Vigouret, and Annelise Jaton pp 754 - 757; DOI: 10.1021/jm00206a007 |
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Synthesis and analgetic activity of some 5-aryl-2-azabicyclo[3.2.1]octanes Helen H. Ong, V. B. Anderson, and Jeffrey C. Wilker pp 758 - 763; DOI: 10.1021/jm00206a008 |
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Diuretic activity of Mannich base derivatives of ethacrynic acid and certain ethacrynic acid analogs Daniel A. Koechel and Gary O. Rankin pp 764 - 769; DOI: 10.1021/jm00206a009 |
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.beta.-Adrenergic blocking agents. 18. 1-(Aryloxy)-3-(arylthioalkylamino)propan-2-ols and 1-substituted alkylthioamino-3-(aryloxy)propan-2-ols H. Tucker and J. F. Coope pp 769 - 773; DOI: 10.1021/jm00206a010 |
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Synthesis and hypotensive activity of N-alkyl-N''-cyano-N'-pyridylguanidines Hans Joergen Petersen, C. Kaergaard Nielsen, and E. Arrigoni-Martelli pp 773 - 781; DOI: 10.1021/jm00206a011 |
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Synthesis and biological activity of new 2-nitroimidazole derivatives Bruno Cavalleri, Giancarlo Volpe, Vittorio Arioli, Fabio Pizzocheri, and Alberto Diena pp 781 - 784; DOI: 10.1021/jm00206a012 |
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A series of hexahydro[1,4]oxazino[3,4-a]isoquinolines as potential neuroleptics Frank H. Clarke, Ronald T. Hill, John Koo, Rose M. Lopano, Miguel A. Maseda, Michael Smith, Steven Soled, Gisbert Von Veh, and Isadoros Vlattas pp 785 - 791; DOI: 10.1021/jm00206a013 |
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Peptidyl transferase substrate specificity with nonaromatic aminoacyl analogs of puromycin Kei-Lai L. Fong and Robert Vince pp 792 - 795; DOI: 10.1021/jm00206a014 |
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Gliotoxin analogs as inhibitors of reverse transcriptase. 1. Effect of lipophilicity Harry C. J. Ottenheijm, Jacobus D. M. Herscheid, Marian W. Tijhuis, Marijn Oosterbaan, and Erik De Clercq pp 796 - 799; DOI: 10.1021/jm00206a015 |
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Gliotoxin analogs as inhibitors of reverse transcriptase. 2. Resolution and x-ray crystal structure determination Harry C. J. Ottenheijm, Jacobus D. M. Herscheid, Marian W. Tijhuis, Rutger J. F. Nivard, Erik De Clercq, and Peter A. J. Prick pp 799 - 804; DOI: 10.1021/jm00206a016 |
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Comparative analysis of the cytotoxicity of substituted [phenylglyoxal bis(4-methyl-3-thiosemicarbazone)]copper(II) chelates. 2. Parabolic correlations and their implications for selective toxicity Eugene A. Coats, Stanley R. Milstein, Michael A. Pleiss, and Jeffrey A. Roesener pp 804 - 809; DOI: 10.1021/jm00206a017 |
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Drugs derived from cannabinoids. 7. Tachycardia and analgesia structure-activity relationships in .DELTA.9-tetrahydrocannabinol and some synthetic analogs Patricia F. Osgood, John F. Howes, Raj K. Razdan, and Harry G. Pars pp 809 - 811; DOI: 10.1021/jm00206a018 |
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Nalorphine-like properties of some 2,3-dimethyl-3-arylpiperidines Maria A. Iorio and Alan F. Casy pp 812 - 815; DOI: 10.1021/jm00206a019 |
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Potential antitumor agents. Synthesis, reactivity, and cytotoxicity of .alpha.-methylene carbonyl compounds John M. Cassady, S. R. Byrn, I. K. Stamos, S. M. Evans, and A. McKenzie pp 815 - 819; DOI: 10.1021/jm00206a020 |
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Antitumor agents. 32. Synthesis and antitumor activity of cyclopentenone derivatives related to helenalin Kuo-Hsiung Lee, Eng-Chun Mar, Masao Okamoto, and Iris H. Hall pp 819 - 822; DOI: 10.1021/jm00206a021 |
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Serotonin receptor binding affinities of several hallucinogenic phenylalkylamine and N,N-dimethyltryptamine analogs Richard A. Glennon, Stephen M. Liebowitz, and Elizabeth C. Mack pp 822 - 825; DOI: 10.1021/jm00206a022 |
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Facile syntheses of potent dopaminergic agonists and their effects on neurotransmitter release A. S. Horn, C. J. Grol, D. Dijkstra, and A. H. Mulder pp 825 - 828; DOI: 10.1021/jm00206a023 |
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In vitro antiplaque properties of a series of alkyl bis(biguanides) Robert A. Coburn, Pamela J. Baker, Richard T. Evans, Robert J. Genco, and Stuart L. Fischman pp 828 - 829; DOI: 10.1021/jm00206a024 |
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Synthesis and biologic distribution of radioiodinated .beta.-adrenergic antagonists Robert N. Hanson, B. Leonard Holman, and Michael A. Davis pp 830 - 833; DOI: 10.1021/jm00206a025 |
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Diethyl (4b.alpha.,4c.alpha.,9a.alpha.,9b.alpha.)-3,6-dichlorocyclobuta[1,2-b:3,4-b']bisbenzofuran-9a,9b(4bH,4cH)-dicarboxylate: the cis, syn photodimer of ethyl 5-chlorobenzofuran-2-carboxylate, an analog related to the antilipidemic drug clofibrate. Donald T. Witiak, Howard A. I. Newman, Guiragos K. Poochikian, Stephen W. Fogt, John R. Baldwin, Christine L. Sober, and Dennis R. Feller pp 833 - 837; DOI: 10.1021/jm00206a026 |
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8-Carboxy-6-sulfamyldibenz[b,f][1,4]oxazepines and -thiazepines as potential high-ceiling diuretics Richard C. Allen, Philip A. Reitano, and Hansjoerg Urbach pp 838 - 840; DOI: 10.1021/jm00206a027 |
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1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent Keith A. M. Walker, Allen C. Braemer, Sharon Hitt, Richard E. Jones, and Thomas R. Matthews pp 840 - 843; DOI: 10.1021/jm00206a028 |
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Book Reviews pp 843 - 844; DOI: 10.1021/jm00206a600 |
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Cerebrovasodilatation through selective inhibition of the enzyme carbonic anhydrase. 1. Substituted benzenedisulfonamides Peter E. Cross, Brian Gadsby, Gerald F. Holland, and William M. McLamore pp 845 - 850; DOI: 10.1021/jm00207a001 |
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Design of potent antagonists of the vasopressor response to arginine-vasopressin Krzysztof Bankowski, Maurice Manning, Jaya Haldar, and Wilbur H. Sawyer pp 850 - 853; DOI: 10.1021/jm00207a002 |
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Structure-activity relationships of aminoalkyl and -aryl glycosides having insulin-like activity Philippe L. Durette, Robert L. Bugianesi, Mitree M. Ponpipom, T. Y. Shen, Margaret A. Cascieri, Monroe S. Glitzer, and Howard M. Katzen pp 854 - 859; DOI: 10.1021/jm00207a003 |
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Photoaffinity labeling of the angiotensin II receptor. 1. Synthesis and biological activities of the labeling peptides Emanuel H. F. Escher, Nguyen Thi Mai Dung, Helene Robert, Domenico C. Regoli, and Serge A. St. Pierre pp 860 - 864; DOI: 10.1021/jm00207a004 |
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Pivaloyl esters of N,N-dialkylated dopamine congeners. Central dopamine-receptor stimulating activity Hakan Wikstrom, Per Lindberg, Per Martinson, Stephan Hjorth, Arvid Carlsson, Uli Hacksell, Uno Svensson, and J. Lars G. Nilsson pp 864 - 867; DOI: 10.1021/jm00207a005 |
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Diacridines, bifunctional intercalators. Chemistry and antitumor activity Teh Kuei Chen, Rosario Fico, and E. S. Canellakis pp 868 - 874; DOI: 10.1021/jm00207a006 |
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Pyridine derivatives as potent inducers of erythroid differentiation in Friend leukemia cells Chau-Der Li, Lana S. Rittmann, Asterios S. Tsiftsoglou, Kuldeep K. Bhargava, and Alan C. Sartorelli pp 874 - 877; DOI: 10.1021/jm00207a007 |
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Stereoelectronic factors in the binding of substrate analogs and inhibitors to purine nucleoside phosphorylase isolated from human erythrocytes Frank Jordan and Annie Wu pp 877 - 882; DOI: 10.1021/jm00207a008 |
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Imidazo[1,2-a]-s-triazine nucleosides. Synthesis and antiviral activity of the N-bridgehead guanine, guanosine, and guanosine monophosphate analogs of imidazo[1,2-a]-s-triazine Sun-Hyuk Kim, David G. Bartholomew, Lois B. Allen, Roland K. Robins, Ganapathi R. Revankar, and Phoebe Dea pp 883 - 889; DOI: 10.1021/jm00207a009 |
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Antiviral activity of some .beta.-diketones. 4. Benzyl diketones. In vitro activity against both RNA and DNA viruses G. D. Diana, Philip M. Carabateas, Robert E. Johnson, Gordon L. Williams, Francis Pancic, and Joseph C. Collins pp 889 - 894; DOI: 10.1021/jm00207a010 |
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Analgesic activity of novel spiro heterocycles. 2-Amino-7-oxa-3-thia-1-azaspiro[5.5]undec-1-enes and related compounds Noal Cohen, Bruce L. Banner, Rocco J. Lopresti, and Herman W. Baruth pp 895 - 900; DOI: 10.1021/jm00207a011 |
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Antiinflammatory and analgesic diastereoisomeric derivatives of indan-5-acetic acid J. M. Teulon, J. C. Cognacq, F. Hertz, J. M. Lwoff, M. Foulon, F. Baert, M. J. Brienne, L. Lacombe, and J. Jacques pp 901 - 905; DOI: 10.1021/jm00207a012 |
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Synthesis and antiinflammatory evaluation of substituted isophthalonitriles and trimesonitriles, benzonitriles, and terephthalonitriles William P. Heilman, Robert D. Battershell, William J. Pyne, Paul H. Goble, Thomas A. Magee, and Richard J. Matthews pp 906 - 913; DOI: 10.1021/jm00207a013 |
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Nondepressant .beta.-adrenergic blocking agents. 1. Substituted 3-amino-1-(5,6,7,8-tetrahydro-1-naphthoxy)-2-propanols Michael E. Condon, Christopher M. Cimarusti, Rita Fox, V. L. Narayanan, Joyce Reid, Joseph E. Sundeen, and Fred P. Hauck pp 913 - 922; DOI: 10.1021/jm00207a014 |
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Structure-activity study of .beta.-adrenergic agents using the SIMCA method of pattern recognition W. J. Dunn, Svante Wold, and Y. C. Martin pp 922 - 930; DOI: 10.1021/jm00207a015 |
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N,N'-(phenylene)dioxamic acids and their esters as antiallergy agents John B. Wright, Charles M. Hall, and Herbert G. Johnson pp 930 - 935; DOI: 10.1021/jm00207a016 |
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Structure-activity correlations for a series of antiallergy agents. Oxanilic, quinaldic, and benzopyran-2-carboxylic acids B. Vernon Cheney, John B. Wright, Charles M. Hall, Herbert G. Johnson, and Ralph E. Christoffersen pp 936 - 940; DOI: 10.1021/jm00207a017 |
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Antiallergic activity of tetracyclic derivatives of quinoline-2-carboxylic acid. 2. Some benzothienoquinolinecarboxylic acids James J. Wade, Edward H. Erickson, Ramon F. Hegel, Larry R. Lappi, and Thomas K. Rice pp 941 - 948; DOI: 10.1021/jm00207a018 |
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Reactions of chlorpromazine cation radical with physiologically occurring nucleophiles Hung-Yuan Cheng, Patricia Holt Sackett, and Richard L. McCreery pp 948 - 952; DOI: 10.1021/jm00207a019 |
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Synthesis and biological evaluation of some 2-amino-4-aryl-3H-1,5-benzodiazepine analogs of clozapine Charles R. Ellefson, Chi M. Woo, Arni Miller, and Janet R. Kehr pp 952 - 957; DOI: 10.1021/jm00207a020 |
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N7-Substituted 7-aminoactinomycin D analogs. Synthesis and biological properties M. S. Madhavarao, Michael Chaykovsky, and Sisir K. Sengupta pp 958 - 961; DOI: 10.1021/jm00207a021 |
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Semisynthetic cephalosporins. Synthesis and structure-activity relationships of 7-(1-pyrryl)- and 7-(1-indolyl)acetamidocephalosporin derivatives A. Nudelman, H. Karoly, F. Braun, E. H. W. Bohme, and R. C. Erickson pp 962 - 964; DOI: 10.1021/jm00207a022 |
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Synthesis and analgesic activity of 1,3-dihydro-3-(substituted phenyl)imidazo[4,5-b]pyridin-2-ones and 3-(substituted phenyl)-1,2,3-triazolo[4,5-b]pyridines Robert L. Clark, Arsenio A. Pessolano, Tsung-Ying Shen, David P. Jacobus, Howard Jones, Victor J. Lotti, and Lars M. Flataker pp 965 - 978; DOI: 10.1021/jm00207a023 |
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Effects of thiophene analogs of chloroamphetamines on central serotonergic mechanisms S. Conde, R. Madronero, M. P. Fernandez-Tome, and J. Del Rio pp 978 - 981; DOI: 10.1021/jm00207a024 |
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Cardioselectivity as a function of molecular structure in .beta.-adrenoceptor blocking agents of the 1-(para-substituted aryloxy)-3-(isopropylamino)propan-2-ol type Mordechai Erez, Gad Shtacher, and Marta Weinstock pp 982 - 984; DOI: 10.1021/jm00207a025 |
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Antiallergic activity of tetracyclic derivatives of quinoline-2-carboxylic acids. 1 Edward H. Erickson, Larry R. Lappi, Thomas K. Rice, Karl F. Swingle, and Michael Van Winkle pp 984 - 988; DOI: 10.1021/jm00207a026 |
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Synthesis and prostaglandin-like activity of 2-(trans-3-hydroxy-1-octenyl)-3-indoleheptanoic acid A. Barco, S. Benetti, G. P. Pollini, P. G. Baraldi, M. Guarneri, D. Simoni, C. B. Vicentini, P. G. Borasio, and A. Capuzzo pp 988 - 990; DOI: 10.1021/jm00207a027 |
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Synthesis and xanthine oxidase inhibitory analysis of 1H-pyrrolo[3,2-c]pyridine-4,6(5H,7H)-dione (3,7-dideazaxanthine) and two of its derivatives S. W. Schneller, R. S. Hosmane, L. B. MacCartney, and D. A. Hessinger pp 990 - 993; DOI: 10.1021/jm00207a028 |
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Cyclic analogs of luteinizing hormone-releasing hormone with significant biological activities Janos Seprodi, David H. Coy, Jesus A. Vilchez-Martinez, Escipion Pedroza, W. Y. Huang, and Andrew V. Schally pp 993 - 995; DOI: 10.1021/jm00207a029 |
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Synthesis of 2-substituted primaquine analogs as potential antimalarials Raghav V. Shetty and C. DeWitt Blanton pp 995 - 998; DOI: 10.1021/jm00207a030 |
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Book Reviews pp 999 - 1000; DOI: 10.1021/jm00207a600 |
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A structure-carcinogenicity study of 4-nitroquinoline 1-oxides using the SIMCA method of pattern recognition W. J. Dunn and Svante Wold pp 1001 - 1007; DOI: 10.1021/jm00208a001 |
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Synthesis and biochemical evaluation of inhibitors of estrogen biosynthesis Robert W. Brueggemeier, E. Elizabeth Floyd, and R. E. Counsell pp 1007 - 1011; DOI: 10.1021/jm00208a002 |
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11,12-Secoprostaglandins. 5. 8-Acetyl- or8-(1-hydroxyethyl)-12-hydroxy-13-aryloxytridecanoic acids and sulfonamide isosteres as inhibitors of platelet aggregation John B. Bicking, James H. Jones, Wilbur J. Holtz, Charles M. Robb, Frederick A. Kuehl, David H. Minsker, and Edward J. Cragoe pp 1011 - 1018; DOI: 10.1021/jm00208a003 |
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Synthesis and biological activity of highly active .alpha.-aza analogs of luliberin Anand S. Dutta, Barrington J. A. Furr, Michael B. Giles, and Barbara Valcaccia pp 1018 - 1024; DOI: 10.1021/jm00208a004 |
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Studies on vitamin D (calciferol) and its analogs. 15. 24-Nor-1.alpha.,25-dihydroxyvitamin D3 and 24-nor-25-hydroxy-5,6-trans-vitamin D3 Antonio Mourino, Patricia Blair, Wayne Wecksler, R. Lorne Johnson, Anthony W. Norman, and William H. Okamura pp 1025 - 1029; DOI: 10.1021/jm00208a005 |
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Cholecystokinin (pancreozymin). 4. Synthesis and properties of a biologically active analog of the C-terminal heptapeptide with .epsilon.-hydroxynorleucine sulfate replacing tyrosine sulfate Miklos Bodanszky, Jean Martinez, Gareth P. Priestley, Jerry D. Gardner, and Viktor Mutt pp 1030 - 1035; DOI: 10.1021/jm00208a006 |
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Synthesis and antiinflammatory activity of 6,11-dihydro-11-oxodibenzo[b,e]thiepinalkanoic acids and related compounds Jack Ackrell, Yulia Antonio, Fidencio Franco, Rosita Landeros, Alicia Leon, Joseph M. Muchowski, Michael L. Maddox, Peter H. Nelson, Wendell H. Rooks, and et al. pp 1035 - 1044; DOI: 10.1021/jm00208a007 |
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2-Pyrrolidinylideneureas, a new class of central nervous system agents C. R. Rasmussen, Joseph F. Gardocki, James N. Plampin, Barbara L. Twardzik, Brian E. Reynolds, Albert J. Molinari, Norman Schwartz, Walter W. Bennetts, Beth E. Price, and Janis Marakowski pp 1044 - 1054; DOI: 10.1021/jm00208a008 |
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A new warfarin metabolite: structure and function Michael J. Fasco, Paul P. Dymerski, J. David Wos, and Laurence S. Kaminsky pp 1054 - 1059; DOI: 10.1021/jm00208a009 |
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Antimalarial drugs. 39. Folate antagonists. 13. 2,4-Diamino-6-[(.alpha.,.alpha.,.alpha.-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effects Edward F. Elslager, Patricia Jacob, Judith Johnson, Leslie M. Werbel, Donald F. Worth, and Leo Rane pp 1059 - 1070; DOI: 10.1021/jm00208a010 |
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Synthetic sulfur-containing amino acids. Inhibition of transport systems in S37 ascites tumor cells Neil J. Lewis, Roger L. Inloes, Jan Hes, Richard H. Matthews, and George Milo pp 1070 - 1073; DOI: 10.1021/jm00208a011 |
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Synthesis of potential hypolipidemic agents. Reaction of substituted phenyl 2,3-epoxypropyl ethers with adenine, uracil, and thymine William S. DiMenna, Claude Piantadosi, and Robert G. Lamb pp 1073 - 1076; DOI: 10.1021/jm00208a012 |
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Synthesis and carcinogenic activity of 5-fluoro-7-(oxygenated methyl)-12-methylbenz[a]anthracenes Melvin S. Newman, Lewis E. Fikes, Mohamed M. Hashem, R. Kannan, and V. Sankaran pp 1076 - 1078; DOI: 10.1021/jm00208a013 |
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Synthesis and pharmacological activity of a phosphate ester of .DELTA.8-tetrahydrocannabinol Hidetoshi Yoshimura, Kazuhito Watanabe, Kazuta Oguri, Michihiro Fujiwara, and Showa Ueki pp 1079 - 1081; DOI: 10.1021/jm00208a014 |
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2-Methoxyphenylethanolamines, potential .beta.-adrenergic blocking agents Lyall R. Williams, Bui V. Lap, Chen H. Lim, Diana M. Temple, Peter A. Easson, and Gordon L. Letts pp 1081 - 1084; DOI: 10.1021/jm00208a015 |
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New synthetic routes to tilorone dihydrochloride and some of its analogs Helen M. Burke and Madeleine M. Joullie pp 1084 - 1086; DOI: 10.1021/jm00208a016 |
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Derivatives of 1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H)-dione as anxiolytic agents William B. Wright, Herbert J. Brabander, Eugene N. Greenblatt, Ivana P. Day, and Robert A. Hardy pp 1087 - 1089; DOI: 10.1021/jm00208a017 |
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Book Reviews pp 1089 - 1092; DOI: 10.1021/jm00208a600 |
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Novel analgesic-antiinflammatory salicylates J. Hannah, W. V. Ruyle, H. Jones, A. R. Matzuk, K. W. Kelly, B. E. Witzel, W. J. Holtz, R. A. Houser, T. Y. Shen, and et al. pp 1093 - 1100; DOI: 10.1021/jm00209a001 |
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Synthesis and analgesic-antiinflammatory activity of some 4- and 5-substituted heteroarylsalicylic acids Howard Jones, Michael W. Fordice, Ronald B. Greenwald, John Hannah, Arlene Jacobs, William V. Ruyle, G. Lyn Walford, and T. Y. Shen pp 1100 - 1104; DOI: 10.1021/jm00209a002 |
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Synthesis and analgetic activity of some benzomorphan analogs Tadashi Kometani and Shunsaku Shiotani pp 1105 - 1110; DOI: 10.1021/jm00209a003 |
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Synthesis, opiate receptor affinity, and conformational parameters of [4-tryptophan]enkephalin analogs Peter W. Schiller, Chun F. Yam, and Janie Prosmanne pp 1110 - 1116; DOI: 10.1021/jm00209a004 |
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Psychotropic agents. 3. 4-(4-Substituted piperidinyl)-1-(4-fluorophenyl)-1-butanones with potent neuroleptic activity Makoto Sato, Masahiro Arimoto, Katsujiro Ueno, Hiroshi Kojima, Terukiyo Yamasaki, Takeo Sakurai, and Akira Kasahara pp 1116 - 1120; DOI: 10.1021/jm00209a005 |
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Benzopyrones. 14. Synthesis and anti-allergic properties of some N-tetrazolylcarboxamides and related compounds G. P. Ellis, G. J. P. Becket, D. Shaw, H. K. Wilson, C. J. Vardey, and I. F. Skidmore pp 1120 - 1126; DOI: 10.1021/jm00209a006 |
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Molecular properties of the adrenergic .alpha. receptor. 2. Optimum covalent inhibition by two different prototypes of polyamine disulfides Carlo Melchiorre, Man Sen Yong, Bruno G. Benfey, and Bernard Belleau pp 1126 - 1132; DOI: 10.1021/jm00209a007 |
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Structure-activity relationships for the inhibition of acrosin by benzamidine derivatives R. F. Parrish, J. W. Straus, J. D. Paulson, K. L. Polakoski, R. R. Tidwell, J. D. Geratz, and F. M. Stevens pp 1132 - 1136; DOI: 10.1021/jm00209a008 |
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Use of adenine nucleotide derivatives to assess the potential of exo-active-site-directed reagents as species- or isozyme-specific enzyme inactivators. 2. Isozyme-specific inactivation of a mammalian enzyme and its significance in the possible design of fetal isozyme targeted antineoplastic agents Alexander Hampton, Francis Kappler, Mitsuaki Maeda, and Arvind D. Patel pp 1137 - 1140; DOI: 10.1021/jm00209a009 |
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Synthesis and biological activities of some uronic acids, uronates, uronamides, and urononitriles of pyrimidine nucleosides Raymond F. Schinazi, Ming S. Chen, and William H. Prusoff pp 1141 - 1146; DOI: 10.1021/jm00209a010 |
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Phosphorus-nitrogen compounds. 22. Synthesis and antitumor activity of arylsulfonylhydrazones L. A. Cates, D. J. Good, G. S. Jones, and T. L. Lemke pp 1146 - 1149; DOI: 10.1021/jm00209a011 |
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Synthesis of spiro[isobenzofuran-1(3H),4'-piperidines] as potential central nervous system agents. 4. Central nervous system depressants Michael L. Cornfeldt, Stuart Fielding, Harry M. Geyer, and Jeffrey C. Wilker pp 1149 - 1154; DOI: 10.1021/jm00209a012 |
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Three-dimensional mapping of the sweet taste receptor site Piero A. Temussi, Francesco Lelj, and Teodorico Tancredi pp 1154 - 1158; DOI: 10.1021/jm00209a013 |
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2-(Substituted phenyl)oxazolo[4,5-b]pyridines and 2-(substituted phenyl)oxazolo[5,4-b]pyridines as nonacidic antiinflammatory agents Robert L. Clark, Arsenio A. Pessolano, Bruce Witzel, Thomas Lanza, T. Y. Shen, C. Gordon Van Arman, and Edwin A. Risley pp 1158 - 1162; DOI: 10.1021/jm00209a014 |
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Potential anticancer agents. 16. Methotrexate analogs with a modified peptide side chain Dan Carol Suster, Eutanta Tarnauceanu, Dumitru Ionescu, Vasile Dobre, and Ion Niculescu-Duvaz pp 1162 - 1165; DOI: 10.1021/jm00209a015 |
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Potential anticancer agents. 17. Analogs of methotrexate with a tripeptide side chain Dan Carol Suster, Eutanta Tarnauceanu, Georgeta Botez, Vasile Dobre, and Ion Niculescu-Duvaz pp 1165 - 1167; DOI: 10.1021/jm00209a016 |
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Potential bis-alkylating agents for cancer chemotherapy. Approaches to the synthesis of 2-sulfonyl-1,4-bis(dimethanesulfonoxy)butanes James M. Wilbur pp 1168 - 1171; DOI: 10.1021/jm00209a017 |
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Synthesis and some pharmacological properties of the 23-peptide 15-lysine-secretin-(5-27). Special role of the residue in position 15 in biological activity of the vasoactive intestinal polypeptide Miklos Bodanszky, Sesha Natarajan, Jerry D. Gardner, Gabriel M. Makhlouf, and Sami I. Said pp 1171 - 1173; DOI: 10.1021/jm00209a018 |
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Synthesis and .beta.-adrenoceptor activity of the erythro and threo isomers of substituted .alpha.-hydroxytrimetoquinol Peter Osei-Gyimah, Michael T. Piascik, John W. Fowble, Dennis R. Feller, and Duane D. Miller pp 1173 - 1178; DOI: 10.1021/jm00209a019 |
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Synthesis of substituted 1-hydroxy-2-naphthanilides as potential cestodicidal agents S. K. Dubey, A. K. Singh, H. Singh, S. Sharma, R. N. Iyer, J. C. Katiyar, P. Goel, and A. B. Sen pp 1178 - 1181; DOI: 10.1021/jm00209a020 |
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Book Reviews pp 1181 - 1184; DOI: 10.1021/jm00209a600 |
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Aromatic hydroxylation of .beta.-adrenergic antagonists. 4- and 5-Hydroxylation of 1-(isopropylamino)-3-[2-(allyloxy)phenoxy]-2-propanol (oxprenolol) Wendel L. Nelson and Terrence R. Burke pp 1185 - 1186; DOI: 10.1021/jm00210a001 |
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Plant antitumor agents. 17. Structural requirements for antineoplastic activity in quassinoids M. E. Wall and M. C. Wani pp 1186 - 1188; DOI: 10.1021/jm00210a002 |
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Collagenase-sensitive peptidyl-nitrogen mustards as potential antitumor agents Mark J. Marquisee and James C. Kauer pp 1188 - 1194; DOI: 10.1021/jm00210a003 |
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Stereoselective effects of cis- and trans-cyclopropylbis(dioxopiperazines) related to ICRF-159 on metastases of a hamster lung adenocarcinoma Donald T. Witiak, Hee J. Lee, H. Duane Goldman, and Bruce S. Zwilling pp 1194 - 1197; DOI: 10.1021/jm00210a004 |
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Synthesis and pharmacological evaluation of a clofibrate-related tricyclic spirolactone, 5-chloro-4',5'-dihydrospiro[benzofuran-2(3H),3'(2'H)-furan]-2'-one Donald T. Witiak, Richard C. Cavestri, Howard A. I. Newman, John R. Baldwin, Christine L. Sober, and Dennis R. Feller pp 1198 - 1202; DOI: 10.1021/jm00210a005 |
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Inhibition of four human serine proteases by substituted benzamidines Judith M. Andrews, Daniel P. Roman, David H. Bing, and Michael Cory pp 1202 - 1207; DOI: 10.1021/jm00210a006 |
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Molar volume relationships and the specific inhibition of a synaptosomal enzyme by psychoactive cannabinoids Jeffrey H. Greenberg, Alan Mellors, and John C. McGowan pp 1208 - 1212; DOI: 10.1021/jm00210a007 |
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Synthesis and antiviral and enzymic studies of certain 3-deazaguanines and their imidazolecarboxamide precursors P. Dan Cook, Lois B. Allen, David G. Streeter, John H. Huffman, Robert W. Sidwell, and Roland K. Robins pp 1212 - 1218; DOI: 10.1021/jm00210a008 |
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Prodrugs of 9-.beta.-D-arabinofuranosyladenine. 1. Synthesis and evaluation of some 5'-(O-acyl) derivatives David C. Baker, Theodore H. Haskell, and Sterling R. Putt pp 1218 - 1221; DOI: 10.1021/jm00210a009 |
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Haloacetamido analogs of 2-amino-2-deoxy-D-glucose and 2-amino-2-deoxy-D-galactose. Syntheses and effects on the Friend murine erythroleukemia Thomas P. Fondy, Susan B. Roberts, Asterios S. Tsiftsoglou, and Alan C. Sartorelli pp 1222 - 1225; DOI: 10.1021/jm00210a010 |
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Neuroleptics related to butaclamol. An investigation of the effects of chlorine substituents on the aromatic rings Leslie G. Humber, Niko Sideridis, Andre A. Asselin, Francois T. Bruderlein, and Katherine Voith pp 1225 - 1231; DOI: 10.1021/jm00210a011 |
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Synthesis and biological activity of .beta.-endorphin and analogs. Additional evidence for multiple opiate receptors Simon Lemaire, Alain Berube, Gilles Derome, Irma Lemaire, Jacques Magnan, Domenico Regoli, and Serge St. Pierre pp 1232 - 1235; DOI: 10.1021/jm00210a012 |
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(2-exo-3-endo)-2-Aryltropane-3-carboxylic esters, a new class of narcotic antagonists Robert L. Clarke, Anthony J. Gambino, Anne K. Pierson, and Sol J. Daum pp 1235 - 1242; DOI: 10.1021/jm00210a013 |
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(exo,exo)-2-Aryltropane-3-carboxylic esters, hypoglycemic agents with accompanying analgesic activity Robert L. Clarke, Monica L. Heckeler, Anthony J. Gambino, Sol J. Daum, Homer R. Harding, Anne K. Pierson, David G. Teiger, Jack Pearl, Leon D. Shargel, and Thomas J. Goehl pp 1243 - 1253; DOI: 10.1021/jm00210a014 |
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Synthesis and antiinflammatory activity of some 1,2,3- and 1,2,4-triazolepropionic acids Robert T. Buckler, Harold E. Hartzler, Elva Kurchacova, Gust Nichols, and Barrie M. Phillips pp 1254 - 1260; DOI: 10.1021/jm00210a015 |
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4-(6-Methoxy-2-naphthyl)butan-2-one and related analogs, a novel structural class of antiinflammatory compounds Alexander C. Goudie, Laramie M. Gaster, Antony W. Lake, Carl J. Rose, Patricia C. Freeman, Bryn O. Hughes, and David Miller pp 1260 - 1264; DOI: 10.1021/jm00210a016 |
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Studies on 1-substituted 4-(1,2-diphenylethyl)piperazine derivatives and their analgesic activities. 2. Structure-activity relationships of 1-cycloalkyl-4-(1,2-diphenylethyl)piperazines Kagayaki Natsuka, Hideo Nakamura, Toshiyuki Negoro, Hitoshi Uno, and Haruki Nishimura pp 1265 - 1269; DOI: 10.1021/jm00210a017 |
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Synthesis and antihypertensive activity of 5-thio-2-pyridinecarboxylic acid derivatives Neville Finch, Thomas R. Campbell, Charles W. Gemenden, Michael J. Antonaccio, and Henry J. Povalski pp 1269 - 1274; DOI: 10.1021/jm00210a018 |
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2,5,5-Trimethylthiazolidine-4-carboxylic acid, a D(-)-penicillamine-directed pseudometabolite of ethanol. Detoxication mechanism for acetaldehyde Herbert T. Nagasawa, David J. Goon, and Eugene G. DeMaster pp 1274 - 1279; DOI: 10.1021/jm00210a019 |
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Biologically active derivatives of angiotensin for labeling cellular receptors Richard E. Galardy, Sally S. Stafford, Mary Lee Schaefer, Helen Ho, Kathleen A. LaVorgna, and James D. Jamieson pp 1279 - 1283; DOI: 10.1021/jm00210a020 |
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Trichloroacetamidines, a new class of positive inotropic agents Walfred S. Saari, Mark B. Freedman, Joel R. Huff, Stella W. King, Andrew W. Raab, Susan J. Bergstrand, Edward L. Engelhardt, Alexander Scriabine, George Morgan, and et al. pp 1283 - 1290; DOI: 10.1021/jm00210a021 |
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Pharmacology of some metabolites of triazolam, alprazolam, and diazepam prepared by a simple, one-step oxidation of benzodiazepines Martin Gall, B. V. Kamdar, and R. J. Collins pp 1290 - 1294; DOI: 10.1021/jm00210a022 |
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Absolute configuration of (+)-5-(3-hydroxyphenyl)-5-phenylhydantoin, the major metabolite of 5,5-diphenylhydantoin in the dog James H. Maguire, Thomas C. Butler, and Kenneth H. Dudley pp 1294 - 1297; DOI: 10.1021/jm00210a023 |
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Calculated properties of arene oxides of biological interest. 1. Molecular orbital examination of simple models Max M. Marsh and Donald M. Jerina pp 1298 - 1301; DOI: 10.1021/jm00210a024 |
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Synthesis and quantitative structure-activity relationships of some antibacterial 3-formylrifamycin SV N-(4-substituted phenyl)piperazinoacethydrazones Judith A. Kiritsy, David K. Yung, and David E. Mahony pp 1301 - 1307; DOI: 10.1021/jm00210a025 |
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Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 7. Role of the ribosyl moiety in enzymatic binding of S-adenosyl-L-homocysteine and S-adenosyl-L-methionine Ronald T. Borchardt, Yih Shiong Wu, and Bi Shia Wu pp 1307 - 1310; DOI: 10.1021/jm00210a026 |
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Inhibition of beef-brain and dog-heart (sodium(1+) + potassium(1+) ion) activated adenosine triphosphatase by carbon-3 branched cardenolides Hans Ulrich Siebeneick and Willi Hoffmann pp 1310 - 1312; DOI: 10.1021/jm00210a027 |
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Pharmacology on rat ileum of certain 2-substituted 3-(dimethylamino)-5,6-dimethoxyindenes related to 5,6-(methylendioxy)indene calcium antagonist Donald T. Witiak, Sunil V. Kakodkar, George E. Brunst, John R. Baldwin, and Ralf G. Rahwan pp 1313 - 1315; DOI: 10.1021/jm00210a028 |
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Antitumor activity of 1,2-diaminocyclohexaneplatinum complexes against Sarcoma-180 ascites form Yoshinori Kidani, Kenji Inagaki, Masaaki Iigo, Akio Hoshi, and Kazuo Kuretani pp 1315 - 1318; DOI: 10.1021/jm00210a029 |
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2,5-Bis(3,4-dimethoxybenzyl)cyclopentylamine, a peripheral dopamine blocking agent Charles H. Jarboe, Steve F. Lipson, Michael J. Bannon, and Daniel A. Dunnigan pp 1318 - 1320; DOI: 10.1021/jm00210a030 |
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Synthesis and antinociceptive activity of 7-methoxycodeine Ikuo Iijima, Junichi Minamikawa, Kenner C. Rice, and Arthur E. Jacobson pp 1320 - 1322; DOI: 10.1021/jm00210a031 |
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2,6-Methano-3-benzazocine-11-propanols. Lack of antagonism between optical antipodes and observation of potent narcotic antagonism by two N-methyl derivatives William F. Michne pp 1322 - 1324; DOI: 10.1021/jm00210a032 |
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Electronic aspects of the antibacterial action of sulfanilamides Pier G. De Benedetti, Augusto Rastelli, Michele Melegari, and Albano Albasini pp 1325 - 1327; DOI: 10.1021/jm00210a033 |
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Antiallergic activity of some 9H-xanthen-9-one-2-carboxylic acids James A. Bristol, Robert Alekel, James Y. Fukunaga, and Martin Steinman pp 1327 - 1330; DOI: 10.1021/jm00210a034 |
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Synthesis and gastric antisecretory properties of an 8-aza- and a 10-oxa-8,12-secoprostaglandin Phillip A. Zoretic, Peter Soja, and Thomas Shiah pp 1330 - 1332; DOI: 10.1021/jm00210a035 |
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Antineoplastic properties of arylsulfonylhydrazones of 3-formylpyridazine 2-oxide and 4-formylpyrimidine 3-oxide Jesse A. May and Alan C. Sartorelli pp 1333 - 1335; DOI: 10.1021/jm00210a036 |
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Antimycotic imidazoles. 2. Synthesis and antifungal properties of esters of 1-[2-hydroxy(mercapto)-2-phenylethyl]-1H-imidazoles Keith A. M. Walker, Donald R. Hirschfeld, and Michael Marx pp 1335 - 1338; DOI: 10.1021/jm00210a037 |
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.alpha.-(2-Pyridine)benzyl aryl ketones as potential hypocholesteremic agents L. E. Hewitt, D. R. Wade, J. E. Sinsheimer, J. Huipo Wang, J. C. Drach, and J. H. Burckhalter pp 1339 - 1340; DOI: 10.1021/jm00210a038 |
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Book Reviews pp 1341 - 1345; DOI: 10.1021/jm00210a600 |
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Additions and Corrections - New Synthetic Calcium Selective Ionophores. Design, Synthsis, and Transport Properties. Michael J. Umen, and A. Scarpa pp 1340 - 1340; DOI: 10.1021/jm00210a601 |
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Additions and Corrections - 6β[N,N-Bis(2-chloroethyl)amino]-17-(cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxymorphinan(Chlornaltrexamine), a Potent Opioid Receptor Alkylating Agent with Ultralong Narcotic Antagonist Activity P. S. Portoghese, D. L .Larson, J. B, Jiang, A. E. Takemori, and T. P. Caruso pp 1340 - 1340; DOI: 10.1021/jm00210a602 |
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Additions and Corrections - Studies of Antitumor Agents. 2. Syntheses and Antitumor Activities of 1-(Tetrahydro-2-furanyl)-5-fluorouracil and 1,3-Bis(tetrahydro-2-furanyl)-5-flourouracil Mitsugi Yasumoto, Ichiro Yamawaki, Teruyoshi Marunaka, and Sadao Hashimoto pp 1340 - 1340; DOI: 10.1021/jm00210a603 |